Many millions of years ago, a massive meteor made of pure Vibranium crashes in central Africa. It affects the plant life around it, imbuing it with strength, prosperity, and mysticism. As the time of human intelligence comes, five tribes in East Africa settle on the land where the vibranium meteor struck and call it Wakanda.
About 10,000 BC, the five tribes of Wakanda live in constant war with each other until, one day, a warrior shaman named Bashenga receives a vision from the panther goddess Bast, who leads him to the Heart-Shaped Herb. Bashenga ingests the plant and it grants him superhuman strength, speed, and instincts. He becomes king and the first Black Panther, the protector of Wakanda. While four of the tribes agree to live under Bashenga's reign, the Jabari Tribe instead choose to isolate themselves in the mountains.
The Wakandans eventually use the powerful technology created with Vibranium, and the advantage of being Earth’s only source of it, to hide themselves from the rest of the world. The kings of Wakanda use the Heart-Shaped Herb that grows near the original vibranium impact site to become the Black Panther.
The great-grandfather of Ulysses Klaue is killed by the Black Panther of Wakanda.
Prince N’Jobu, acting as a spy for Wakanda, heads to Oakland, California. The racial disparity he encounters causes him to believe Wakanda should abandon its isolationist stance and arm oppressed people across the globe. N’Jobu secretly works with arms dealer Ulysses Klaue to steal Vibranium from Wakanda, and in the process, several people are killed, including the parents of W’Kabi, a friend of Prince T’Challa.
King T’Chaka comes to Oakland and confronts N’Jobu, killing him in the dispute. T’Chaka leaves behind N’Jobu’s young son, N’Jadaka, known in the U.S. as Erik Stevens, rather than return the boy to Wakanda.
T’Challa returns to Wakanda for his coronation, officially becoming king and Black Panther. When Ulysses Klaue resurfaces, T’Challa and his allies team with the CIA to capture Klaue, but Klaue is rescued by his ally, Erik Stevens, who is also known by his U.S. Special Forces nickname, Killmonger.
T’Challa returns to Wakanda and admits he couldn’t stop Klaue, but soon after, Killmonger arrives in Wakanda with Klaue’s body. Killmonger uses killing Klaue, an enemy of Wakanda, and his status as N’Jobu’s son to challenge T’Challa and become king. T’Challa’s allies manage to escape before Killmonger can harm them, and later find T’Challa’s injured body, reviving him using the Heart-Shaped Herb.
Killmonger prepares to use Vibranium weapons to arm people across the world and create a Wakandan-led revolution. T’Challa returns and eventually defeats and kills Killmonger, but decides to end Wakanda’s isolationist practices in favor of using the nation’s wealth and technology to help the rest of the world.