The Ancient One was the Sorcerer Supreme as well as the leader of the Masters of the Mystic Arts. For centuries, the Ancient One protected Earth from mystical threats, and dedicated herself to helping others in need by educating them in the magical arts to give them new hope. However, later on, she was challenged by a former student, Kaecilius, who had become corrupted by the Dark Dimension and sought to bring Dormammu to Earth.

Species: Human

Gender: Female

Date of Birth: 1316-1317

In the midst of her war against Kaecilius and his Zealots, the Ancient One encountered Doctor Strange and, despite her initial reluctance, was persuaded to accept him as her student by Karl Mordo.

During one final battle, the Ancient One was fatally wounded and despite the best efforts of Doctor Strange and Christine Palmer, she accepted her fate and died, but not before giving Doctor Strange the advice he needed to defeat Dormammu as well as to find his new purpose in life as a master.